In a market economy, each industrial enterprise aims to increase the economic efficiency of its activities. The aim of the study is to systematize the factors of increasing the economic efficiency of industrial enterprises. There are many classifications of factors that affect the efficiency of the enterprise. On the example of enterprises of the chemical industry of the Smolensk region, factors were considered and a model was proposed to increase the economic efficiency of their activities.

This book analyzes unobvious relations between historical definitions of the face and its contemporary usage in popular culture and social media, like Facebook or Instagram. Bringing together a wide range of methodologies, it includes essays from manifold disciplines of the humanities such as philosophy, literary and art criticism, media and television studies, game studies, sociology and anthropology. The authors focus on both metaphorical and material meanings of the face. They grapple with crucial questions about modernity, modern and postmodern subjectivity, as (...) well as with origins of certain linguistic terms and popular, colloquial phrases based on the concept of the face. (shrink)

Dans le champ de la linguistique francaise, Olga Galatanu est de ceux qui ont muni l'analyse du discours et des interactions verbales d'un modele semantique de description. La Semantique des Possibles Argumentatifs qu'elle developpe depuis une vingtaine d'annees adhere aux visions argumentative, stereotypique, referentielle, cognitiviste de la langue, et s'attache a rendre compte de la construction des representations en langue et en discours.<BR> Les articles que ses collaborateurs et amis lui offrent dans ce volume se rapportent de pres ou (...) de loin a la SPA. Certains en partagent les postulats: sens referentiel et denomination, interfaces semantique-syntaxe et semantique-pragmatique, construction discursive du sens, valeurs; d'autres reprennent et developpent des elements specifiques de la SPA: possibles argumentatifs, deploiements argumentatifs, modalites; d'autres encore montrent les convergences et complementarites entre la SPA et des theories voisines.<BR> Les analyses portent notamment sur l'attitude metalinguistique des locuteurs, la malleabilite semantique des mots, la negociation des sens et des valeurs, les principes et strategies discursives qui regulent la communication, l'heterogeneite discursive, la presentation de soi, la construction d'objets discursifs, les actes de langage indirects, etc.". (shrink)

As genomic research becomes commonplace across the world, there is an increased need to coordinate practices among researchers, especially with regard to data sharing. One such way is an international code of conduct. In September 2020, an expert panel consisting of representatives from various fields convened to discuss a draft proposal formed via a synthesis of existing professional codes and other recommendations. This article presents an overview and analysis of the main issues related to international genomic research that were discussed (...) by the expert panel, and the results of the discussion and follow up responses by the experts. As a result, the article presents as an annex a proposal for an international code of conduct for data sharing in genomics that is meant to establish best practices. (shrink)

Confronted with an unprecedented scale of human-induced environmental crisis, there is a need for new modes of theorizing that would abandon human exceptionalism and anthropocentrism and instead focus on developing environmentally ethical projects suitable for our times. In this paper, we offer an anti-anthropocentric project of an ethos for living in the Anthropocene. We develop it through revisiting the notion of sustainability in order to problematize the linear vision of human-centric futurity and the uniform ‘we’ of humanity upon which it (...) relies. We ground our analyses in posthumanism and material feminism, using works by posthumanist and material feminist thinkers such as Stacy Alaimo, Rosi Braidotti, Donna Haraway and Jane Bennett, among others. In dialogue with them, we offer the concept of posthuman sustainability that decenters the human, re-positions it in its ecosystem and, while remaining attentive to difference, fosters the thriving of all instances of life. (shrink)

This article investigates discursive practices associated with the co-management of patients between healthcare providers. Specifically, we focus on two genres written by optometrists and ophthalmologists — two groups who are experiencing interprofessional tension over their scopes of practice. In our analysis we foreground four kinds of modality associated with verbs — epistemic, deontic, phatic and subjective. We found that these healthcare providers shared in the epistemic resources used to hedge their sense of clinical certainty, and that ophthalmologists used deontic resources (...) to control future action. However, we also noted that both professions used deontic, phatic and subjective resources to create dialogical space for each other to participate in some future relationship. In fact, one of the main points of this correspondence might be to establish personal relationships between practitioners. Unfortunately, however, this subtle use of modality to negotiate professional boundaries is fading as many ophthalmologists, due to workload issues, are not responding to referral letters or are converting their correspondence to form letters. (shrink)

When young children learn to use language, they start to use their hands in co‐verbal gesturing. There are, however, considerable differences between children, and it is not completely understood what these individual differences are due to. We studied how children at 4 years of age employ speech and iconic gestures to convey meaning in different kinds of spatial event descriptions, and how this relates to their cognitive abilities. Focusing on spontaneous illustrations of actions, we applied a semantic feature (SF) analysis (...) to characterize combinations of speech and gesture meaning and related them to the child's visual‐spatial abilities or abstract/concrete reasoning abilities (measured using the standardized SON‐R test). Results show that children with higher cognitive abilities convey significantly more meaning via gesture and less solely via speech. These findings suggest that young children's use of cospeech representational gesturing is positively related to their mental representation and reasoning abilities. (shrink)

L’article propose l’analyse de trois formes de manifestation de ce que nous avons appelé l’implicite argumentatif : à visée discursive, à visée sémantique et à visée lexicale. Dans la perspective théorique de la Sémantique des Possibles Argumentatifs, nous avons défini ce phénomène sémantico-discursif, comme la reconstruction, dans l’interprétation du sens d’un énoncé ou d’un ensemble d’énoncés, d’un élément signifiant ou d’une configuration d’éléments signifiants relevant de la nature argumentative de la signification d’un mot, présent ou absent de cet énoncé ou (...) de cet ensemble d’énoncés. L’article défend, illustre et argumente les fondements sémantiques de ces trois types d’implicite argumentatif, ancrés dans le potentiel discursif de la signification des mots et dans le potentiel du sens produit dans les instances de parole, de proposer des significations lexicales régénérées. (shrink)

Populations have different percents on different history realms regarding baths and fountains. A constant historical issue of such places is related with constant use and adore. Therefore we find ourselves in time where they where more used and ages where they where less used. On our paper we analyse from a sociological perspective the use of such spaces, mainly associated with social interaction and sociability. At the end of our paper, we are going to analyse both issues directly linked with (...) tourism perspective in terms of health and care on the so called “Postindustrial Society”. (shrink)

Although epidemiology as a scientific study of disease in populations claimed an independent disciplinary status already in the mid–nineteenth century, its history in the twentieth century can be seen as a continuous and often contentious attempt to define the field’s social and intellectual boundaries vis-à-vis a variety of neighboring scientific fields and public health practices. In a period dominated by laboratory biomedical sciences, epidemiologists repeatedly tried to spell out how their discipline met the requirements of scientificity despite its focus on (...) disease as a collective phenomenon and its reliance on nonlaboratory methods. This article asks about the relationship between the changing institutional and intellectual contexts of British epidemiological practice and the epidemiologists’attempts to define both science in general and epidemiology in particular. An examination of the epidemiologists’boundary-making endeavors is also used to reflect on the circumstances in which scientists engage in the discourse of disciplinary demarcations. (shrink)

Ancient critics reproached Xenocrates for beginning his work on the dialectic with a discussion of voice, and until now the question why he did so has never been systematically explored. Neither do we know why Xenocrates counted syllables, as Plutarch reports, and how he arrived at such an implausibly high number. In the first part of this paper, I show that Xenocrates’ interest in voice was suggested by Plato’s discussion of letters in his later dialogues, such as the Theatetus, the (...) Sophist, the Statesman, and the Philebus. Second, a fragment from Sextus attributed to Xenocrates confirms that Xenocrates allowed for various ‘levels’ of elements, and that explains why Theuth’s method, recommended in the Philebus, is applied to syllables. Finally, I address the very possibility of knowing the actual number of syllables and words, and address some of the problems connected to the reconstruction of the mathematical argument. (shrink)

In common law jurisdictions, legal professionals cite facts and legal principles from precedent cases to support their arguments before the court for their intended outcome in a current case. This practice stems from the doctrine of stare decisis, where cases that have similar facts should receive similar decisions with respect to the principles. It is essential for legal professionals to identify such facts and principles in precedent cases, though this is a highly time intensive task. In this paper, we present (...) studies that demonstrate that human annotators can achieve reasonable agreement on which sentences in legal judgements contain cited facts and principles. We further demonstrate that it is feasible to automatically annotate sentences containing such legal facts and principles in a supervised machine learning framework based on linguistic features, reporting per category precision and recall figures of between 0.79 and 0.89 for classifying sentences in legal judgements as cited facts, principles or neither using a Bayesian classifier, with an overall κ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\kappa$$\end{document} of 0.72 with the human-annotated gold standard. (shrink)

At the bedside, nurses are expected to be precise when they read indications on screens and on the bodies of patients and decide on the meaning of words framed by the context of acute care. In academia, although there is no incident report to fill when we misread or misrepresent complex philosophical ideas, the consequences of inaccurate reading include misplaced epistemological claims and poor scholarship. A long and broad convention of nursing phenomenological research, in its various forms, claims a philosophical (...) grounding in the ideas of Husserl, Heidegger, and other thinkers. But for nearly two decades, nurse phenomenologists' knowledge claims have been challenged by well‐informed criticisms, most notably by John Paley. At the heart of criticism lies an observation that Continental phenomenological thought is misrepresented in many nursing sources and that nursing phenomenology, both descriptive and interpretive, cannot appeal to the authority of either Husserl or Heidegger. Taking these criticisms seriously, I am asking, Is phenomenology after Paley possible? If misreading seems to be an issue, how can – or should – we read rigorously? My thinking through these questions is influenced by the ideas of Jacques Derrida. Under a condition of a play of language, of Derridian différance, when meaning is never self‐identical and never fully arrives, I suggest that one has to negotiate meanings through reading for differences. I develop this idea in relation to the methodological conventions of phenomenological nursing research and argue for a careful rereading of the whole field of phenomenological nursing research. Such rereading presupposes and necessitates interdisciplinary engagement between nursing and the humanities and interpretive social sciences. Greater familiarity with research practices of those disciplines that stress theoretical and writing rigour might make visible the limits of nursing research approaches and their quality criteria. An understanding of philosophical and theoretical works – a condition of quality scholarship – depends on our reading of both originary texts and contemporary literature from the humanities and the social sciences. This understanding, far from obliging researchers to always trace (often erroneously) their work to its philosophical roots, opens other, often more sound, methodological possibilities. (shrink)

The article is dedicated to considering ethnic tourism in its importance to comprehend modern cultures that are Others to the traveler's experience. In this regard, ethnic tourism is presented from the Other's cognition, i.e., the way of life of a nation, its religious and ethnic values and traditions, historical past and legends, and geographical specificity of residence. Thus, the meaning of ethnic tourism is related to the human desire to discover other cultural and social spaces. Simultaneously, the article shows how (...) another culture's perception affects the awareness of a tourist's identity. The author notes that ethnic tourism aims at fixing the distinctive features and specifics of people's life. Therefore, this type of tourism is most conducive to forming images and perceptions of ethnic and cultural diversity. The author substantiates the role of ethnic tourism to establish a dialogue of cultures in the modern world. Distinctive features of globalization, particularly travelers' continuous mobility, the conversation of ethnic groups, and the value-based mutual enrichment of peoples, have been deduced. Some theoretical approaches of Russian philosophers to the study of ethnic tourism are defined. The researcher emphasizes the idea of a correlation between ethnic cultures and religions. In this regard, early Christianity's theological ideas are conditioned in terms of their impact on the subsequent formation of pilgrimages and the modern religious tourism organization. The contemporary unity of ethnic culture and religiosity is vividly manifested in the uniqueness of the Old Believers' tradition of the Kerzhak resettlers living in the Altai Mountains. The article concludes that ethnicity should be acknowledged in any tourism organization, especially religious and pilgrimage types. (shrink)

Based on exploration of activities of the joint Russian-Ukrainian historical commission, the paper addresses the interpretation of events of the Ukrainian Revolution of 1917-1921 by historical schools and some researchers of the Russian Federation, specifically O. Chubarian, T. Tairova-Yakovleva, O. Zaitsev, D. Bondarenko, V. Mikhailov et al., who generally assess the work of Ukrainian historians as unfounded revision of the revolutionary events of 1917-1921 for the purpose of simulating the historical process as a number of tragedies, plots, devastators etc. It (...) is established that by denying the Ukrainian Revolution events as a restoration process of Ukrainian statehood and formation of Ukrainian identity as well as by denying subsequent Bolshevist intervention and assessing those events as an internal civil conflict, Russian historians actually maintain that Ukraine is an integral part of the Russian superpower and has no history of its own. The author defines such interpretation of the 1917-1921 events and refusal to recognize specific features of the Ukrainian Revolution, which are spread in academic community and mass media of the RF, as information and propaganda activities along with perversion of other events of the historical past of Ukraine. (shrink)

The Russian Federation conducts an information policy in the Baltic direction, aimed at forming a negative image of Latvia, Lithuania and Estonia in the international scene through involving research and development institutions, Russian media and social networks to informational propaganda. Main forms and methods of destructive influence on Russian-speaking population of the Baltic countries have been identified in previous studies. So, the Baltic countries for a long time are in the epicentre of cyber and information attacks by Russian Federation. The (...) aim of the study is to analyze the activities of the Latvia, Lithuania and Estonia of formation of national systems for ensuring cyber security in historical retroperspective, the provisions of the documents of the European Union and NATO in this area. The article is based on the documentary sources from 2004 to 2016. The contents of the guidance documents on issues of cyber security of the Baltic countries meets the requirements of the governing documents of NATO in this sphere аnd involves activities in three directions: protecting its own infrastructure from hacker attacks; international cooperation in this sphere and the involvement of civil experts. Тhat is we can see implementation of all these directions in the Baltic countries. Feature of information security in the Baltic States is focusing on issues related to cyber security. This is primarily due to high level of Informatization in there countries and their membership in European Union and NATO. (shrink)

This article discusses the corporeal component of the human mind. Uncertainty is a fundamental attribute of the human body due to which a body transforms itself into the body that allows to connect the world with the human mind. The process of overcoming the transcendental register of the human mind results in the ontological and anthropological shifts from ego to soma. Tracing the trajectory of these shifts we discover the bodily dimension in the human mind as its constitutive transcendental ground. (...) This dimension makes the mind not only open to the world but makes the world a part of the human mind. It prevents the mind from exerting power over the world, and gives rise to life vitality of the embodied mind. (shrink)

The main purpose of this book is to investigate, from the philosophical point of view, the concept of mind in some quickly developing fields of contemporary science, from physics and cosmology to biology and cognitive science. New scientific investigations have brought many empirical results that help to explain natural phenomena from quantum states to human thinking, yet the question of the nature of the mind itself is still open. In this book, the authors discuss several philosophical problems raised or reformulated (...) by recent scientific discoveries. The authors use an interdisciplinary and holistic approach that bridges the gap between scientific and humanistic pictures of the mind. (shrink)

En este volumen se recogen una serie de estudios, reflexiones y propuestas prácticas en torno a las nociones de violencia, justicia y libertad. Sus responsables consideran que es urgente reflexionar sobre ellas, pues nuestras acciones, nuestra respuesta o nuestra indiferencia ante la violencia o la injusticia, dependen de lo que entendamos por un Estado justo o lo que signifique para nosotros ser libre. Partiendo de diferentes tradiciones filosóficas y de autores que han abordado estas cuestiones a lo largo de la (...) historia, nos preguntamos qué relación hay actualmente entre la violencia, la justicia y la libertad: ¿es la libertad sin límites necesariamente violenta? ¿Se puede luchar por la justicia con medios violentos, sin caer en la injusticia? ¿Contribuye nuestra sociedad a la realización de un mundo más justo? (shrink)

_“Religious Freedom: Social-Scientific Approaches”_ offers original research on religious freedom from around the globe. The volume addresses the issues related to defining and understanding the concept of religious freedom with interdisciplinary methods and by incorporating sociological thinking as a constituent part of this analysis.

This commentary is an attempt to give a Vygotskian perspective on Carpendale's & Lewis's (C&L's) target article. The article uses ideas that are well familiar to Vygotsky's scholars. However, it develops these ideas further and raises important empirical questions about the role of social interaction in the development of social cognition. The article provides a fresh view on the old problems and frames themes traditional for the English-speaking developmental psychology into a broader international perspective.

In Theriaca 343–358, Nicander recounts a rather unusual myth. After Prometheus had stolen fire, Zeus was seeking the thief and, when men delivered Prometheus over to him, he gave them the gift of youth. Humans entrusted the ass to carry this load, but the ass was seized by thirst and sought the help of the snake, who demanded in return the thing he was carrying on his back. This is how the gift of youth given to men fell to the (...) serpent’s lot. Ever since, inevitable old age has weighed upon them, while the snakes cast off their old skin and gain a new one. Like any digression in Hellenistic epic poetry, this parable certainly is intended to entertain the reader, yet it must have a more serious function: by showing that it was only out of stupidity that men gave away their invaluable gift to the ass, Nicander asserts the great value of knowledge for life. Remarkably, it is precisely in this passage that the poet has inserted the acrostic of his name. The idea that his poetic work will ensure the survival of his name for future generations, directly expressed in the closing lines, is here conveyed with the greatest refinement. (shrink)

The main subject of this research is the specificity of I. E. Repin's perception of the dynamics of artistic-aesthetic tasks formed under the influence of changing modernity. In view of this, one of the compositional centers of the research is the history of relationship that developed between I. E. Repin and the artists of the “first wave of symbolism” – members of the association “The World of Art”. Special attention is given to the question of perception of I. E. Repin (...) by certain representatives of the avant-garde in 1910s. Developing in the range “attraction – negation”, full of dramatic and comic moments, the dialogue between Repin and younger generation indicates the hastiness of univocal view of realism and Art Nouveau as opposing imagery systems. For the first time, on the current level of scientific comprehension of the aesthetics of symbolism and neo-romanticism, the article analyzes the attitude of I. E. Repin towards the innovative imagery pursuits of the Art Nouveau artists. At the same time, the very concept of Art Nouveau is interpreted in two dimensions: as a certain milestone in the context of the development of the history of art of the late XIX – early XX century; and as an inner dynamic potential embedded by I. E. Repin in his works since the beginning of his creative path. Based on systematization of the artistic and documentary sources and the method of complex reconstruction of the views of Peredvizhniki and symbolist artists upon the objectives and nature of art, the author concludes that the poetics of art of Ilya Repin, synthesizing the ideas of time, tends to reflect a complicated and distinctive artistic image formed by realistic and idealistic principles. (shrink)

The article is dedicated to the development of theatrical art in Mariupol at the beginning of 20th century. The theatrical life of Mariupol has not been investigated yet as an original art phenomenon, and therefore, it demands for the detailed studying. There are the repertoire, the role of touring troupes and development of charitable activities of actors in the city described in the article as well. The information was collected from literature, newspapers and funds of local lore museums. The study (...) showed us the rising of ideological and educational value of the scene provincial theaters at the beginning of XX c. In Mariupol worked several theaters, which created conditions for the formation of theater seasons, touring groups' arrivals and also the base for the development of local amateur groups. Performances of guest performers - Ukrainian, Russian and foreign stars of theater scene contributed to the promotion and enrichment of theatrical culture, transforming Mariupol into the cultural centers of the region. The author considers the features of the state policy in the sphere of theatrical art during the Civil War and in the first years of Soviet government power. The Soviet government made a circle of attempts to use the theater in the business of agitation and propaganda as much as possible. In consequence with nationwide problems, the conditions which theater city institutions worked in, сconsiderably got worsened because of the fact of the demand of entertaining genres in the repertoire of the theaters. Nevertheless, thanks to the safekeeping of the best examples of the theatrical traditions, the priorities in the repertoire policy were given to the Ukrainian, Russian and foreign classics. In conclusion, it may be said also, that theater in Mariupol at the beginning of XX c., was developed, despite the complications that have been appeared under the influence of existing political regime and differed from others in the existence of various professional and amateur groups, wide touring guest activities of the prominent masters of the stage and diverse repertoire. (shrink)

One of the signs of the rapid development of medical genetics is a gradual increase in the number of genetic tests available. Different aspects of this phenomenon have been addressed and debated in the source literature, but so far relatively little has been said about the obligation to provide equal access – in the social context – to selected kinds of tests. In this article, I attempt to reconstruct those few suggestions, dealing with the principles of funding genetic tests from (...) public resources, that can still be found in the source literature. Accordingly, I have analyzed the possibilities of identifying the criteria of selecting diagnostic and preventive tests to be eligible for refund, as well as of screening programmes. (shrink)

The article deals the activities of social and political organizations of pro-Russian direction on the Crimea peninsula. The author defines that under the banner of maintaining relations with compatriots and the preservation of social and cultural traditions, was carried out targeted information campaign on the formation of anti-Ukrainian sentiment among the youth. Events on the Crimean peninsula, unfortunately, belong to insufficiently studied issues of recent history of Ukraine. Ukrainian historical opinion have demonstrated passivity on this issue and no sound labor (...) opposed promotional products of famous Russian historians and historical schools. Starting from the first day of the independence of Ukraine our "eastern neighbor" carried out targeted information pressing supported by numerous pro-Russian social organizations, which the peninsula has always been rich in. Types of propaganda rhetoric, methods and forms of action changed according to the political and military significance of events that took place. Рro-Russian social organizations have organized different initiatives to involve youth organizations. For example, there is the observance of the military patriotic youth camp Donuzlav anti NATO. (shrink)

In the recent linguistic literature, an increasing attention has been devoted to the role of force dynamics in natural language. The present paper argues that the concept of force plays an important role in the Finnish case system. Translative case in this language is conventionally associated with change of state and the illative and allative cases, with change of location. Unexpectedly under such an approach, these forms are sometimes acceptable in sentences that do not entail a change and superficially seem (...) to be stative. This paper argues that translative, illative and allative are licensed by predicates that entail force exertion. While in many instances, force exertion results in a change, this is not an obligatory configuration, which explains the distribution of the cases under discussion. (shrink)

Obviously, it is about the Ukrainian Greek Catholic Church. I, the author of the article, suggest looking at her, taking into account all her hypostasis, its ritual and organizational peculiarities, but to focus on how this Church performs one of the functions that are inherent in religious systems and organizations: a value-controlling function, and how this performance correlates with the national interests of Ukrainians.

The purpose of the article is to study the influence of Nazi experiments on the formation of ideas about the ethos of science in the field of biomedicine. It is shown that the idea of discrediting a value-neutral science was often confronted with the resistance of the scientists themselves, who, in different contexts of condemning Nazi crimes, appealed to the fact that they acted for the good of science, and even of all mankind. The article discusses the strategy of American (...) lawyers adopted at the Nuremberg Trials aimed at demonstrating the perversity of Nazi crimes in the field of biomedicine both ethically and scientifically. In addition, an analysis of individual materials of the Nuremberg process was carried out, which made it possible to give an idea of the scientific and linguistic design of the human body (name correction strategy) as a “correct” scientific object with desired properties. The article considers the influence of the data obtained on Nazi crimes on the formation of the content of the Nuremberg Code and the design of the principle of informed consent in biomedicine. Ethical aspects related to the further use of Nazi scientific data are also considered. In conclusion, the problem of the formation of scientific knowledge in non-violence mode is articulated. (shrink)

Relevance of the article is determined that the effective functioning of the reinsurance market greatly depends on the development of its infrastructure because it creates opportunities for implementation of reinsurance services, mediates, accelerates and facilitates placement and execution of reinsurance contracts. Given the state of the domestic insurance market mediation necessary means to enhance its development and integration into the global reinsurance market. The article is a study of measures to enhance the role of mediation in the insurance market of (...) Ukraine. The article provided a critical assessment of the legal status of insurance mediation in Ukraine. Factors that determine its role in the insurance market of Ukraine. Established quantitative and cost indicators of intermediation of brokers in insurance and reinsurance, given their logical explanation. Suggestions to create appropriate conditions for the development of mediation in the insurance and reinsurance markets in Ukraine. Mediation plays an important role in the development of the insurance market of Ukraine since: helping the participants to choose the most optimal proposal for the establishment of additional guarantees of the insurance liabilities; strengthening partnerships and trust between the reinsurer and the reinsurer; improves the quality and dynamics of sales reinsurance services; supports a healthy competitive environment in the reinsurance market. It was established that the quantitative and cost indicators of intermediation of brokers in insurance and / or reinsurance in Ukraine do not match. By number of deals leadership position with insurers-residents, the cost - non-resident reinsurers. The most attractive segment for mediation turned provision of agreements with non-resident reinsurers for property insurance. To create the appropriate conditions for the development of mediation in the insurance and reinsurance markets of Ukraine should: increase transparency of brokers to introduce their professional liability insurance and the formation of guarantee funds. (shrink)

Globalization processes mean, among other things, the spread of trends that determine the socio-religious development of a region to other spatial areas. This does not happen with an inevitable necessity, it is not a ubiquitous feature of globalization, but it does happen with a very high probability. Moreover, when it comes to development within the same confessional systems. In this context, it is pertinent to note that some of the widespread forms of religious practices in Ukraine today, and moreover, religious (...) structures, fifteen or twenty years ago, seemed to be exclusively Western. This is especially true of the large number of denominations, movements and movements that are Protestant in origin and are referred to as "evangelical" in English literature. (shrink)

Emerging evidence suggests that DNA topology plays an instructive role in cell fate control through regulation of gene expression. Transcription produces torsional stress, and the resultant supercoiling of the DNA molecule generates an array of secondary structures. In turn, local DNA architecture is harnessed by the cell, acting within sensory feedback mechanisms to mediate transcriptional output. MYC is a potent oncogene, which is upregulated in the majority of cancers; thus numerous studies have focused on detailed understanding of its regulation. Dissection (...) of regulatory regions within the MYC promoter provided the first hint that intimate feedback between DNA topology and associated DNA remodeling proteins is critical for moderating transcription. As evidence of such regulation is also found in the context of many other genes, here we expand on the prototypical example of the MYC promoter, and also explore DNA architecture in a genome-wide context as a global mechanism of transcriptional control. Torsional stress, and supercoiling generated by transcription, shape the topology of DNA. Furthermore, the resultant secondary DNA structures and their interacting partners provide feedback to regulate gene expression. Emerging evidence suggests these mechanisms, identified through analysis of the MYC promoter, are applicable genome-wide. (shrink)